During ferroptosis, cells release the DAMP high-mobility group box 1 (HMGB1) by autophagy-dependent processes
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He describes it as a gastric pentadecapeptide synthesised from gastric juice, says its tolerated well even orally, and says injecting it at the site of an injury helps call platelets to that location (source)
Its four-residue sequence alanine, glutamic acid, aspartic acid, and glycine gives it two acidic side chains, making the molecule negatively charged at physiological pH
For hair growth, the relevant signaling pathways are: vascular stimulation (more blood flow to the dermal papilla), follicle repair (extending the anagen growth phase), inflammation modulation (calming the chronic low-grade inflammation that contributes to follicular miniaturization), and systemic growth signaling (IGF-1 levels that influence overall regenerative capacity)
