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Analysis of the D dhar mutant showed that DHARs are required to couple hydrogen peroxide metabolism to glutathione oxidation, and that this is functionally important for downstream activation of the salicylic acid pathway

doi: 10.1111/j.1525-1438.2005.00432.x 121 Villalona-CaleroMAOttersonGAWientjesMGWeberFBekaii-SaabTYoungDet al

In vitiligo patients skin, activated innate immune cells (e.g., DCs and NK cells) secrete multiple pro-inflammatory cytokines and chemokines, including IL-1, IL-6, IFN-, TNF-, CXCL10, and CCL2 (94, 95)

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Testing for B12 deficiency is recommended in symptomatic patients or those with risk factors