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Oxidative stress occurs when the production of ROS or RNS exceeds the antioxidant capacity of the cells, resulting in structural damage and oxidative modifications to proteins, lipids, and nucleic acids

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This gradual approach triggers more nerve responses than quick insertion

Drugs were administered intraperitoneally or centrally (lateral or fourth ventricle) to evaluate the potential for a forebrain and/or hindbrain central site of action

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