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To the extent that melanotan II produces melanogenesis, this is thought to be caused by activation of the MC1 receptor, whereas its clinically documented sexual effects are thought to be related to its ability to activate the MC4 receptor (though the MC3 is thought to possibly also be involved)

Several potential mechanisms may be operative

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It is one of the first inflammatory signals released when the immune system perceives a threat, and in psoriasis, it acts as a master switch that amplifies virtually every other inflammatory pathway involved