Paradoxically, the transient exercise-induced rise in pro-inflammatory cytokines (e.g., TNF-, IL-1, IL-6) triggers subsequent production of anti-inflammatory mediators, reactive oxygen and nitrogen species (O2, NO), and manganese superoxide dismutase (Mn-SOD)
In addition, it enhances thermogenesis (the process by which the body generates heat and burns calories), resulting in increased energy expenditure and decreased fat
Combats oxidation of fatty acids present in the bloodstream, including cholesterol, which slows the process of plaque formation in the arteries, Eye protection: Protects eyesight, keeping it in a correct state and avoiding the appearance of pathologies such as cataracts
At present, the lack of large-scale, confirmatory clinical trials specifically targeting MC4R deficiency is largely due to significant scientific and clinical heterogeneity, which has made conducting such trials logistically challenging and commercially less appealing compared to pursuing broader or more clearly defined patient populations
Mt Sinai J Med
