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This confirmed the role of oxidative stress in the pathogenesis of melasma

As a result, Melanotan II users may experience severe side effects, including: * Facial redness or flushing , * Headaches * Nausea or vomiting * New moles or increased growth of existing moles * Breathing problems * Racing heart * Fever or general malaise * Swollen lymph nodes * Permanent hyperpigmentation * Prolonged erections (in men) * Somnolence * Kidney infarction * Rhabdomyolysis * Skin cancer Case reports have documented the development of melanoma following Melanotan II use, as well as rapid changes in moles and pigmented lesions that can make the detection of skin cancer more difficult, says Deborah S

I.ZilberingA.MahadevK.MotoshimaH.YaoJ.et al (2005)

Uricase-knockout mice have glucose intolerance and are more susceptible to development of diabetes [23, 35]