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Poly-ADP ribose polymerases (PARP 117) control nuclear stability and DNA repair

Melatonin not only regulates the sleep-wake cycle but also serves as a powerful antioxidant that helps reduce oxidative stress and inflammationtwo major contributors to aging and chronic disease Reiter et al., Endocrine , 2006

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NAD+ is therefore a central experimental tool and reference compound in preclinical ageing biology research, where it is used both as a direct supplement and as a biochemical endpoint in studies examining the efficacy of NAD+-boosting interventions