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Neuroprotective properties of GLP-1RAs observed in animal models of neurodegenerative diseases such as Alzheimers disease are very often associated with the reduction of inflammatory processes in the central nervous system

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A 75-year-old man with type 2 diabetes was switched from 14 mg daily of oral semaglutide (Rybelsus) to subcutaneous tirzepatide

SGLT2 inhibitors appear more effective in mitigating glomerular hyperfiltration and lowering heart failure risk, whereas GLP-1 receptor agonists are particularly beneficial in reducing albuminuria and atherosclerotic cardiovascular events

Is there additive benefit of use of GLP-1 receptor agonists and SGLT2 inhibitors for prevention of cardiovascular and renal events