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Peripheral anorexigenic mechanisms The postprandial satiety has been ascribed to numerous signaling molecules, expressed and released in the gastrointestinal tract and also in hypothalamic ARC, to inhibit food intake via activation of the receptors on afferent (mostly vagal) nerves stimulating the satiety center and inhibiting the feeding center (9) ( Fig

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GIP/GLP-1 SGLT2DPP4GLP-1 GIP/GLP-1 GIP/GLP-1 GIP/GLP-1 GIPglucose-dependent insulinotropic polypeptide: GLP-1glucagon-like peptide 1: -1 GLP-1 5mg 1.0mgSURPASS-25mg1mg-7.6kg15mg-11.2kg SURPASS-21mg5mg/40HbA1c2%HbA1c2% N Engl J Med 385(6):503-15,2021. 2SRPUSS J-monoHbA1c7.067HbA1c 7.094 GIPGLP-1 111 GIP/GLP-12023 2022 SURPASS-J-mono GLP-1 / 9 FORTUNE DREAM

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