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Gordon, O.D

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PMID 15363636

doi: 10.1126/science.aan5931 180 PushalkarSHundeyinMDaleyDZambirinisCPKurzEMishraAet al

longum isolates) or synbiotic formulations can reduce diet-induced hepatic lipid accumulation, lower serum ALT/AST and systemic inflammatory markers, and restore gut barrier integrity effects that are mechanistically linked to increased SCFA and ILA production, activation of AMPK/PPAR-dependent hepatic lipid oxidation pathways, and favourable remodelling of bile-acid pools (FXR/TGR5 signalling) (100102)