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Baseline comparison identified several significantly different metabolites, along with an enriched percentage of yet-to-be identified compounds

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Published sensitization studies report rates below 1% in patch testing panels, and no carcinogenic or reproductive toxicity signals have emerged in long-term surveillance data

Our findings lend support to a novel pharmacological approach and demonstrate that metformin can serve as a promising therapeutic agent for IIRI by enhancing the production of microbial GSH, thereby mitigating intestinal ferroptosis

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