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TK models have been used as tools for the estimation of chemical-specific adjustment factors (CSAFs) associated with the POD of both animal models and humans (Rezvanfar 2005)

These toxic reactions are especially pronounced within the hepatocytes, but also proceed in other organs such as the kidney

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Histological examination and histomorphometrical analysis Ovarian samples were taken from all groups of females at the conclusion of the trial, preserved for 24 h in a 10% neutral buffer formalin solution, and then prepared for histochemical and immunohistochemical staining

Each method has its own pros, cons, and suitability depending on your lifestyle and skin goals