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Another study [44] with uremic patients with some degree of muscular atrophy, reports that 24-week treatment with l-carnitine (2 g IV at the end of hemodialysis, or in dialysis solution, or per os twice daily) leads to an increase of about 7% in the diameter of type I and type IIa fibers, as well as to a reduction in atrophic fibers

& Cotter, M

Growth factor-mediated recovery research also investigates IGF-1 LR3, which acts downstream of GH signaling to directly activate insulin-like growth factor receptor pathways in target tissues

Figure adapted from DeWitt & Hirsch (2003)

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