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A clinical review noted that orally administered glutathione "cannot be relied upon for therapeutic purposes," which is why researchers and clinicians have used precursor strategies (NAC, GlyNAC) or IV delivery to achieve meaningful systemic increases

The compound crosses the blood-brain barrier efficiently after oral administration and demonstrates sustained cognitive benefits even after treatment cessation, suggesting true structural enhancement rather than temporary stimulation

Because theophylline is no longer widely used or recommended for the treatment of asthma given its potential for toxicity, additional studies in asthma are needed

With combined activation (CagriSema) the effect does not add linearly, but supra-additively , which is why the combination has a stronger clinical result than either component alone

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