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Patients must have a BMI over 30, or a BMI over 27 with one associated condition like hypertension or Type 2 diabetes, and have been unable to lose and keep off weight with lifestyle changes alone (diet, exercise), says Martin

The fatty acid chain modifications that allow tirzepatide to bind to albumin in the blood (extending its half-life to roughly 5 days for the injectable form) do not protect the core peptide from enzymatic degradation in the gut

doi: 10.1186/2045-7022-4-S3-P23