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The other drawback is that some people who are sensitive to higher histamine levels or who have mast cell activation syndrome report that NAC gives them a histamine reaction

Consult your healthcare provider before combining these medications with glutathione supplements

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197 ALA has antioxidant and anti-inflammatory effects, independent of effects on insulin metabolism, that may play a role in its therapeutic effect

Additionally, the interplay between GSH and other redox systems such as thioredoxin, glutaredoxin, and catalase remains poorly understood