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Increased oxidative stress, inflammation and lipotoxicity associated with hyperglycaemia and insulin resistance potentially impair vascular endothelial function and increase endothelial permeability, leading to the penetration of glycated and oxidized low-density lipoprotein (LDL) cholesterol into the endothelium, i.e., initiation of atherosclerosis

What labs or health markers should be tracked

Research indicates bariatric surgery can effectively reduce hepatic steatosis, inflammation, fibrosis, and even cirrhosis in patients with MASLD

NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production