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found that the frequency of KGDHC E2 (dihydrolipoamide succinyltransferase) genotypes containing allele 2 was significantly higher in PD group than in control group

The gut microbiota influences levels of bile acids, and AD patients have altered bile acid profiles in serum and cerebrospinal fluid (with higher ratios of toxic vs

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The surgery skips parts of the digestive tract where a key protein for B12 absorption is made

Although astrocyte reactivity is likely in the first instance to be targeted at maintaining CNS homoeostasis and circuit functions, various mechanisms could alter astrocyte functions in potentially detrimental ways, including (i) persistent reactivity may contribute to chronic neurodegenerative disorders or chronic inflammation, (ii) ageing and cellular senescence which may alter and reduce astrocyte functional capacities, or (iii) genetic mutations in diseased astrocytes or polymorphisms may alter normal astrocyte functions or responses