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If you hit week 16 at 1.7 mg with less than 5% loss and no significant cardiometabolic benefit, a frank conversation with your prescriber about alternative agents (tirzepatide, for example) is appropriate

PIONEER 9/10, potwierdziy skuteczno semaglutydu w populacji japoskiej (GLP-1 receptor agonists: an updated review of head-to-head clinical studies PMC) (GLP-1 receptor agonists: an updated review of head-to-head clinical studies PMC), ale nadal globalnie wikszo danych pochodzi z populacji europejskiej/amerykaskiej)

Nat Rev Gastroenterol Hepatol 18(3):196208

Why Its Important on GLP-1 : Reduced appetite and lower food intake can lead to decreased calcium consumption

Mental Health Changes : Report worsening depression, suicidal ideation, or unusual changes in behavior