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TCEP reduces disulfide bonds as effectively as DTT and 2-ME, but does not possess in the structure -SH group and does not have to be removed before certain sulfhydryl-reactive cross-linking reactions

Recently, the Pacold group identified 4-HPPA dioxygenase-like protein (HPDL) as the enzyme responsible for this transformation, using ^18O 2 gas labeling and metabolomics techniques 29

Surprisingly, treatment with ACTH not only reduces CRH, ACTH, and cortisol but also lowers cytokine levels in the serum [283]

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