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Animals were caged together and treated in the same way

Osthole protects the brain tissue against cerebral ischemia-reperfusion injury as shown by histological analysis and cerebral function

9.1 Integrated discussion on mechanistic evidence strength, gaps, and confounding factors (1) Strength ranking of core mechanistic evidence and prioritization for clinical translation Based on a systematic analysis of each nutrient's regulatory pathway, the mechanisms with the strongest evidence for clinical translation are prioritized as follows: Omega-3 polyunsaturated fatty acids (EPA/DHA) anti-inflammatory pathway: Supported by human RCTs (65, 69), which show that EPA/DHA supplementation reduces the levels of pro-inflammatory cytokines (IL-1, IL-6) and improves depressive symptoms

GSSG is reduced to GSH by glutathione reductase, so most of the body is in the reduced form

Next, mitochondrial citrate is transported across the inner mitochondrial membrane via a citrate carrier (CIC or SLC25A1) to support fatty acid synthesis for tumor progression in hypoxia 73 (Fig