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Although doctors may recommend B12 injection for this purpose when weakness is related to peripheral neuropathy, more research is needed on effectiveness, and Medicare doesnt consider this medically necessary

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8 Where results are unclear, serum MMA and homocysteine levels (both of which accumulate with B12 deficiency as discussed above) can also be used to confirm a diagnosis, although homocysteine is not specific to B12 deficiency, as it may also be caused by deficiencies in other B vitamins