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Conclusion: FOXO4-DRI promotes the nuclear export of phosphorylated P53 by inhibiting the binding of FOXO4 to P53 in endothelial cells, thereby facilitating the apoptosis of senescent endothelial cells and alleviating aging

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We previously discovered that, regardless of its activation state, D2R can enhance the membrane expression of DAT and consequently DAT-mediated reuptake of dopamine through their direct protein-protein interaction [23]

In addition, the expression of p-AKT, AKT, p-GSK-3, and GSK-3 in liver tissues was analysed by immunoblotting (lower panel)

In general, the higher the EGRac, the less endogenous FAD is available, thus the poorer the blood riboflavin levels 22