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Long-term heavy drinking disrupts the balance between the brains inhibitory (GABA) and excitatory (glutamate/NMDA) signaling systems

65 Knowing these factors can help people take meaningful, practical steps to reduce their risk of cognitive decline and support cognitive health across the lifespan

Update 09/10/25, 06:59 a.m

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It highlights adipokine-mediated inflammation and macrophage polarization as key drivers of cartilage degradation and suggests integrative therapeutic approaches that address both metabolic and inflammatory factors